Dithizone-induced Paneth cell disruption significantly decreases intestinal perfusion in the murine small intestine
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چکیده
منابع مشابه
Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.
Exogenous glucagon-like peptide-2 receptor (GLP-2R) activation elicits proliferative and cytoprotective responses in the gastrointestinal mucosa and ameliorates experimental small and large bowel gut injury. Nevertheless, the essential physiological role(s) of the endogenous GLP-2R remain poorly understood. We studied the importance of the GLP-2R for gut growth, epithelial cell lineage allocati...
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The purpose of this study is to elucidate the participation of Paneth cells in experimentally induced adenocarcinoma of the intestine. The rats were fed with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) dissolved in drinking water ad libitum at a concentration of 100 micrograms/ml for 28 weeks. They were sacrificed 12 weeks after the last MNNG administration. A number of tumor cells containing l...
متن کاملIdentification of the Paneth cells in chicken small intestine.
The Paneth cells are highly specialized cells in the epithelium of the small intestine of many vertebrate species. These cells reside at the base of crypts of the Lieberkühn and contain abundant secretory granules. Previous studies suggesting the existence of Paneth cells in the chicken (Gallus gallus) remained controversial. Here we seek to identify the Paneth cells in the chicken small intest...
متن کاملPaneth Cell Granule of Mouse Intestine
The Paneth cell secretion of the mouse intestine has been reported to be an acid mucopolysaccharide-protein complex; tryptophan as well as alpha acylamido carboxyl, amino, and phenolic groups of protein have been localized to the characteristic granules by means of histochemical staining procedures (13). Sulfhydryl and disulfide groups of protein have also been localized to the granule (14). Th...
متن کاملPaneth cells and antibacterial host defense in neonatal small intestine.
Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during neonatal infection of the small bowel is not well established. Dithizone selectively damages Paneth cells, and when dithizone-treated newborn rats are infected enterally with Escherichia coli, the ...
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ژورنال
عنوان ژورنال: Journal of Pediatric Surgery
سال: 2019
ISSN: 0022-3468
DOI: 10.1016/j.jpedsurg.2019.02.021